Human articular cartilage zone specific gene expression profiling
نویسنده
چکیده
Introduction: Human articular cartilage (HAC) possesses a unique structure and composition with variations in matrix biochemical composition, cell morphology, cell density, cell metabolism and pericellular matrix (PCM) in discretely organized zonal architectures. The superficial zone (SZ) spans the first 10-20% of full thickness HAC. The middle zone (MZ) is about 40-60% and the deep zone (DZ) that extends into the calcified zone, to preserve cartilage and bone integration accounts for approximately 20-30% of the cartilage volume. In our study, we employed human genome arrays to better resolve the unique gene expression profiles of the SZ, MZ and DZ of healthy HAC.
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